The gap was as little as 11 points at one stage but an impressive 200m left the Sheffield-born athlete 110 points ahead of her Ukrainian rival.
Ennis, 24, had won both opening events but the pivotal moment came when, after two disappointing attempts in the shot-put left her well behind the Ukranian, she found a throw of over 14m to maintain the lead.
Ennis then ran a powerful 200m in a time that would have been good enough for a semi-final in the full 200m event: 23.22s.
EnnisÃ¢â‚¬â„¢ performance capped a good Friday for British athletes that saw Andy Turner win the 110m Hurdles, while Christian Malcolm only just missed out on gold in the MenÃ¢â‚¬â„¢s 200m after a fantastic fight back from France’s Christophe Lemaitre, who completed a sprint double with his 100m title.
Michael Bingham and Martyn Rooney sealed silver and bronze respectively as they were edged out by Beligian Kevin Borlee.
Jenny Meadows secured a bronze medal in the womenÃ¢â‚¬â„¢s 800m despite leading for most of the way before being overtaken by defending champion Mariya Savinova and Yvonne Hak of the Netherlands in silver.
MORE: The latest football news