The 22-year-old completed a £19m move to AC Milan on Thursday morning, with the controversial striker penning a four-and-a-half year deal at the San Siro outfit.
Balotelli scored just one Premier League goal this season, with the former Inter Milan forward struggling to break into Roberto Mancini’s first-team.
And the player’s agent Mino Raiola believes England’s loss will prove Serie A’s gain.
“In England they’ll regret Balotelli for a long time,” Raiola told Sky Sport Italia.
“He is an extreme talent. England has only seen 50 per cent of what he can do.
“Balotelli is a cultural asset. We have decreased by 50 per cent the value of the Premier League and improved by 50 per cent the value of Serie A.
“All journalists in England are sad but the important thing is that we have brought a top player back to Italy.
“This negotiation was very difficult. It seemed to fail six or seven times in the last 60 days, especially because of journalists.
“Manchester City’s owners were also not convinced they wanted to sell Mario. But we worked
step by step.
“Mario’s return is a positive sign for all Italian teams. We had to be calm and balanced – and we were. We thank Milan for believing in this deal at a very difficult time economically.”