The world number one came from a set behind to win his fourth major in Oz, taking just over three hours and 40 minutes to exact revenge on the third seed for his US Open final defeat in August.
Here is the best of the Twitter reaction from the world of sport after Djokovic was crowned champion again.
Olympic cyclist and proud Scotsman Chris Hoy (@chrishoy) sends his commiserations to his compatriot: “Hard luck Andy Murray, still three more attempts left this year. Another Scottish sporting icon is on the TV tonight at 10pm BBC2. Colin McRae.”
Former Australia spin bowler Shane Warne (@warne888) congratulates Djokovic: “Congrats to Djokovic on winning the Australian Open final.. Wanted Andy Murray to win it!”
Manchester United defender Rio Ferdinand (@rioferdy5) is sorry for Murray: “Unlucky @andy_murray – Nole is a machine man.”
England’s World Cup winning scrum-half Matt Dawson (@matt9dawson) agrees with the Red Devils defender: “Novak is a machine!!!”
Olympic bronze medallist diver Tom Daley (@TomDaley1994) enjoyed the final: “Well played @andy_murray, great match!”
Meanwhile, the womens’ champion Victoria Azarenka (@vika7) offers her congratulations to her fellow champion: “Congratulations to @DjokerNole for winning his crown! What an impressive run!”
Murray’s former coach Brad Gilbert (@bgtennisnation) was impressed by Djokovic’s returning: “Djokovic keeps his streak of never letting Muray ace him more then nine times tonight..”
Former Olympic athlete Jonathan Edwards (@JDE66) reckons Murray had chances to really put the pressure on Djokovic: “Remarkable performance from Djokovic – virtually down and out at points during 2nd set in the #AusOpenfinal”
Tottenham midfielder Jermaine Jenas (@jjenas8) reckons the Serbian is just too good for Murray: “Novak is just too good.”
Stoke striker Michael Owen (@themichaelowen) believes there’s no shame in losing to Djokovic: “Shame he couldn’t do it, but being the second best tennis player in the world whilst improving at a rate of knots isn’t a bad position to be in!”
Wales rugby star George North (@George_North) feels Murray’s pain: “Great game of tennis. Gutted for Andy Murray.. But who knew Justin Tipuric could play tennis so well!! #hiddentalent”
Another rugby star Brian Moore (@brianmoore666) backs Murray to make another appearane at a Major final: “Whatever happens, Murray’s game has stepped up to that final level and he will contest more Grand Slam finals.”
Finally, Stoke keeper Asmir Begovic (@asmir1) congratulates his compatriot: “Bravo @DjokerNole. Cestitam!”