Danny Welbeck and Cristiano Ronaldo both scored in the first leg at the Bernabéu, with both sides unbeaten domestically since their clash three weeks ago.
Here is the best of the Twitter reaction from the professionals ahead of what should be a special night in Manchester.
Man-of-the-moment Ronaldo (@Cristiano) says his side have only one aim: “I’m looking forward to return to Old Trafford. I’ve so many good memories there… It will be an exciting game for all and our only goal is to win.”
Former Red Devils striker Norman Whiteside (@NormanWhiteside) is tipping a 2-1 Red Devils victory at Old Trafford: “Up early after my favourite day, big game tonight, bring it on, 2-1 will do the job. Cheers NW.”
United legend Peter Schmeichel (@Pschmeichel1) has got a good feeling about the match: “Good morning all, BIG day and I’ve got a great feeling about tonight #ManUtd!”
Gary Neville (@GNev2), who was part of the 1999 and 2008 Champions League winning sides, reckons United need to hold out until half-time: “Those asking for a prediction, I would take 0-0 at HT. Think of Dortmund/Monaco/Madrid games historically and being sunk before we set sail! The reason I say get to HT 0-0 is to keep the crowd in the game. They will get you through second half. It’s the first half where it can go for me.”
Doncaster Rovers winger David cotterill (@cotterill_david) is tipping United to win: “Predictions for Champions League tonight Man Utd v Real Madrid guys?? I’m going 2-1 Man Utd to win! Ronaldo to cause havoc though!!”
Former Sunderland midfielder Michael Gray (@mickygray33) agrees with the Special One: “Jose Mourinho summed up the game perfectly tonight… The World Will Be Watching… #championsleague Man Utd v Real Madrid.”
United striker Wayne Rooney (@WayneRooney) is listening to the Stereophonics to get him in the right frame of mind: “Just listening to Stereophonics new album. Grafitti on the train. Yes lads, been waiting for this one.”
Former Middlesbrough star Jan Aage Fjortoft (@JanAageFjortoft) enjoys Sir Alex Ferguson’s Ronaldo comparisons: “Answer: – How do you compare the two Ronaldos? Sir Alex: – One is fit and one is fat! #MUFC”
Dutch legend Ruud Gullit (@GullitR) is looking forward to the spectacle: “Today is a great day for football. Can’t wait to see #manchesterunitedagainst #realmadrid….”
Finally, QPR defender Chris Samba (@cs4christsamba1) is excited to see United play after watching Manchester City win last night: “I see Man City still holding on with a win last night, looking forward to the big game tonight.”
ENHANCED ODDS: Get 8/1 on Chelsea, Liverpool and City to win