Alessandro Della Valle’s own goal gave the Three Lions the lead after 12 minutes at the Stadio Olimpico before Oxlade-Chamberlain doubled the hosts’ advantage.
A brace from Jermain Defoe and goals from Ashley Young, Frank Lampard, Wayne Rooney and Daniel Sturridge handed England their biggest victory since October 1987.
“We knew we wanted to come here and get the job done,” Oxlade-Chamberlain told Sky Sports. “The more goals we could score, the better for us.
“I think we were spot on from the start tonight, no-one showed any complacency.
“We showed the opposition real respect throughout the team, not just the boys up front but the boys at the back as well.”
England boss Roy Hodgson singled out Oxlade-Chamberlain and Young for special praise after the rout against the Group H minnows.
“Ashley Young and Alex Oxlade-Chamberlain did very well, and we still have Danny Welbeck and James Milner to play out wide. Our options are very good,” said Hodgson, before expressing his delight at his side’s ruthless display.
“I thought it was very professional performance. Obviously we were a class above our opponents, but it was good for those ones who don’t always get a chance to play to feature.
“It was one of those games where I thought everyone brought their straw to the water.”
England take on group leaders Montenegro in their next World Cup qualifier on Tuesday.
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