The north London side head to the principality looking to overturn a 3-1 first-leg deficit after their surprise defeat by the Ligue 1 side last month.
Arsenal must do what no other side has managed in the Champions League era: win having gone into an away tie needing to score more than once to avoid elimination.
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Monaco are eyeing their first Champions League quarter-final since 2003-04, the season they went all the way to the final.
This is Arsenal’s 15th consecutive appearance in the last 16. However, Arsene Wenger’s men have lost at this stage in each of the last four seasons.
Arsenal have gone 17 games without a draw, winning 14 and losing three.
The Gunners have won nine games this season by a scoreline that would take them through against Monaco, including on Saturday when they made it five league wins in a row with a 3-0 victory over West Ham United. Wenger’s men have scored three or more in 11 of their 44 outings.
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