The trio will not travel to Russia with the rest of the Red Devils squad but Sergio Romero and Antonio Valencia are both back available for selection after missing the weekend’s win at Everton.
Van Gaal also confirmed that James Wilson is to remain in Manchester due to illness but Jesse Lingard looks set to be part of the 20-man travelling party.
Speaking to MUTV on Monday evening, Van Gaal said: “It’s the same amount of injuries so Luke Shaw, Paddy McNair and Ashley Young are not going with us.
“Willo was a little bit ill – Wilson as he is named but, for us, it is Willo – so he shall not travel with us.
“I’ll take 20 players with me. It’s a four-hour flight so, if a player gets ill, I have the other player in my environment.
“Of course that was the reason [Romero and Valencia were absent at Everton]. They have to cope with the jet-lag so I didn’t think it was wise to take them with us against Everton.”
United have lost their last three away games in the Champions League proper, although they did win 4-0 at Club Brugge in the play-offs.
The Red Devils, who are third in the Premier League table and two points behind Manchester City, have won only one of seven matches, home and away, against Russian opposition.
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