The Gunners host the Blues at Stamford Bridge on Sunday afternoon as they look to secure a victory to keep their place at the top of the table.
Arsenal were held to a goalless draw by Stoke City in the Premier League last weekend after their 3-3 thriller with Liverpool last week.
Chelsea head into the game in stuttering form and 19 points behind the Gunners, with Guus Hiddink’s men languishing in 14th place in the Premier League table.
Former Arsenal striker Henry believes that the north London club are set to take their opportunity to beat Chelsea and take a step closer to winning their first title since 2004.
Speaking on Sky Sports News HQ on Friday morning, Henry said: “If you’re Arsenal, there is no better moment to play Chelsea.
“They [Arsenal] could have won at Liverpool, they didn’t – they drew against Stoke City which wasn’t bad when you know what they did to other teams at their place.
“But you have a chance to beat the champions at your place and make a statement that you want to be the new champions.
“There’s nothing better than that – and it’s a London derby.”
Arsenal were beaten 2-0 by Chelsea at Stamford Bridge when the two sides last met in the Premier League back in September.
MORE: The latest football news