The Germany international was not named in the matchday squad as the north London side were held to a frustrating stalemate by the Tigers in the fifth round of the FA Cup on Saturday afternoon.
Ozil has been a regular fixture in the north London side’s first-team this season but Wenger opted not to risk him for the cup clash.
And speaking at his post-match news conference, Wenger explained why he opted to leave Ozil, as well as Aaron Ramsey, out against Steve Bruce’s side.
Wenger told his Arsenal news conference after Saturday’s game: “Mesut Ozil was a bit sick over the week, so I decided to leave him out completely.
“Ramsey has played many games, so that’s why I kept him out.”
Arsenal will be hoping that Ozil will be ready for Tuesday night’s crunch clash with Barcelona in the last 16 of the Champions League at Emirates Stadium.
MORE: The latest football news