The defending champions only have pride to play for after a 10-9 defeat by France at the Stade de France in Paris earlier this month.
Ireland’s defeat was preceded by a 16-16 stalemate with Wales in Dublin after squandering a 13-10 half-time lead.
England have it all to play for after beating Scotland and Italy in their opening two games of the Championship.
First on the bill for the Six Nations weekend is Wales against France at the Millennium Stadium in Cardiff.
Warren Gatland’s side need to beat France to keep their Six Nations championship hopes alive after their draw with Ireland in Dublin.
France have already beaten Italy and Ireland.
Finally, Scotland and Italy will hope to capitalise on Ireland’s poor start and secure victory on Saturday afternoon to avoid the wooden spoon.
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