The defending Premier League champions suffered a 3-1 loss to the Saints at Stamford Bridge earlier this season but are unbeaten in domestic competitions under Guus Hiddink.
Elsewhere, leaders Leicester City will host struggling Norwich City at King Power Stadium as the Foxes look to return to winning ways after a 2-1 loss to Arsenal earlier this month.
Stoke City host 20th-placed Aston Villa at the Britannia Stadium and will be confident of victory after Liverpool were 6-0 winners against Remi Garde last time out.
London clubs Watford and West Ham both have home games this weekend as the Hornets host Bournemouth and the Hammers welcome Sunderland.
The Tipster has compiled the best Premier League offers for punters below ahead of an exciting weekend of action.
Chelsea are unbeaten in 13 domestic games since Hiddink took over the reins at Stamford Bridge. Stoke will fancy their chances of beating a Villa side devoid of confidence. Leicester have the chance to move five points clear of Arsenal and Tottenham ahead of Sunday’s games. While Watford will hope to record a vital three points against 16th placed Bournemouth. The Tipster is offering new Betfair customers enhanced odds of 30/1 on Chelsea, Leicester, Stoke and Watford to win. Click here to sign up for this offer.
For those who fancy including a European fixture in their Saturday accumulator, new Paddy Power customers can get 22/1 enhanced odds on Chelsea, Leicester and Real Madrid to win. Click here to sign up for this offer.
The Premier League leaders have the opportunity to put more breathing space between themselves and title challengers Arsenal and Tottenham ahead of Sunday’s games. Leicester have only lost three games this season and the Canaries are the perfect opponents for Claudio Ranieri’s side to face in a bid to make swift return to winning ways. The Tipster is giving new Betfair customers the opportunity to avail of 4/1 enhanced odds on Leicester to beat Norwich. Click here to sign up for this offer.
If West Ham want to continue their push for a place in Europe next season, victory over Sunderland is a must. The Hammers are unbeaten in 12 home games in all competitions. In fact, the east London side haven’t lost at Upton Park since 22 August! New Paddy Power customers can get special odds of 6/1 on West Ham to beat Sunderland. Click here to sign up for this offer.
Chelsea will face Ronald Koeman’s Southampton side at 15:00 GMT St Mary’s on Saturday 27 February 2016. In the early kick-off, West Ham face Sunderland in Saturday at 12:45 GMT, which will be live on BT Sport in the UK.
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