Mauricio Pochettino’s side have been in irrepressible form in recent weeks and have won five of their last six games in all competitions.
The north London side’s winning run came to an end in Florence on Thursday night but Spurs still managed to salvage a 1-1 draw in the first leg of their Europa League last-32 clash.
Palace have been on a run of their own after registering one win in their last seven games in all competitions.
Tottenham were also 3-1 winners against the Eagles in the Premier League at Selhurst Park on 23 January.
Here are some of the best odds on Tottenham v Crystal Palace as well as an offer on West Ham v Blackburn Rovers.
Spurs are fighting on three fronts this season but Pochettino has the squad depth to cope with the demands of domestic football and Europe. Tottenham are being tipped to win their first Premier League title this term and the visit of Palace presents an opportunity to edge a step closer to their first double since 1961. The Tipster is offering new Paddy Power customers enhanced odds of 5/1 on Tottenham to beat Crystal Palace. Click here to sign up.
For those who fancy Slaven Bilic’s high-flying Hammers to go deep into the FA Cup, Betfair have an 6/1 enhanced odds offer. West Ham have only lost two games in their last 16 outings and knocked out Liverpool after a fifth-round replay earlier this month. The Tipster is offering new Betfair customers enhanced odds of 6/1 on West Ham to beat Blackburn. Click here to sign up.
Tottenham entertain Alan Pardew’s Palace side at 15.00 GMT. For those who also want to catch West Ham v Blackburn, BT Sport 2 will be broadcasting that cup tie at 14.00 GMT.
Terms and conditions apply for all of the betting offers detailed in this post. See websites for full terms and conditions.
Get 8/1 enhanced odds on Tottenham to win or 11/1 enhanced odds on Liverpool to win at White Hart Lane on Saturday afternoon. Click here to sign up now. T&Cs apply.
MORE: Latest Man Utd news
MORE: Latest Arsenal news
MORE: The latest football news