Spurs head into the game in fine form and flying high in second place in the Premier League table after their 1-0 win over Watford last weekend.
The north London side have been touted by many to be genuine contenders for the title this season following their impressive consistent form in the top flight.
City, meanwhile, will be looking to bounce back form the disappointment of their 3-1 defeat at the hands of Leicester City at The Etihad last weekend.
Former Liverpool man Lawrenson is expecting the game to be an open, entertaining affair and is tipping the two sides to share the spoils.
Lawrenson told BBC Sport: “I don’t think the fact the Manchester City players knew Manuel Pellegrini is going to be replaced by Pep Guardiola had anything to do with their poor performance against Leicester last week.
“City were outmuscled, out-thought and outpaced. They were second best in all areas and, apart from Sergio Aguero, their players were unbelievably ordinary.
“They cannot afford to be as bad again, because this is their biggest game of the season when it comes to the title race.
“If Tottenham go to Etihad Stadium and roll them over, then City might not be able to recover.
“It is going to be hard for City because, along with the attacking threat of Harry Kane and Dele Alli, Tottenham’s success is based on a top-class goalkeeper in Hugo Lloris and a very good defence.
“But I actually see a few goals in this game, and I think the points will be shared.”
Tottenham finished fifth last season under Mauricio Pochettino.
Manchester City take on Liverpool in the League Cup final at Wembley later this month.
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