The Red Devils suffered a 2-1 loss to Premier League strugglers Sunderland at a cold, windy Stadium of Light on Saturday afternoon.
Louis van Gaal’s side will look to make an immediate return to winning ways against the Danish champions after dropping down to the Europa League after finishing third in their Champions League group.
Midtjylland have already secured one Premier League scalp this season after a 2-1 aggregate win against Ronald Koeman’s Southampton side in the Europa League play-offs in August.
They won their only previous match in Manchester, beating Manchester City FC 1-0 in the first leg of a 2008/09 Uefa Cup second qualifying round tie. They lost the return fixture by the same scoreline, bowing out 4-2 on penalties.
United’s six encounters with Danish teams have ended W4 D1 L1 (W2 D1 L0 at home – W2 D0 L1 in Denmark).
MORE: Latest Man Utd news
MORE: Latest Arsenal news
MORE: The latest football news