The Blues captain has been out of action since the 5-1 Premier League win over Newcastle United last month due to a hamstring injury.
Although the veteran defender has not suffered a setback in his recovery, Hiddink admitted that the former England skipper will probably miss Wednesday’s Champions League last-16 second leg in west London.
Speaking to Chelsea’s website, Hiddink said: “We’d like to have all our defensive players available, but I don’t think John will make Wednesday.
“For the time being there has not been enough development to put him on the list on Wednesday. It’s not worse – he can run, but he still cannot go into a longer stretch which you do when you accelerate – there he must be careful.”
The Blues interim boss was somewhat more optimistic about the chances of Diego Costa being back available for selection after the striker was sidelined with a tendon injury.
The manager continued: “He had a little bit of a problem with a tendon. He could have started, to be honest, but then the risk was there and afterwards I might be left saying, ‘Why did I risk him?'”
Chelsea, who drew 1-1 with Stoke at Stamford Bridge on Saturday in the Premier League, head into their game with PSG trailing the Ligue 1 champions 2-1 after the first leg in Paris last month.
MORE: Man United latest news
MORE: Arsenal latest news
MORE: Chelsea latest news
MORE: Liverpool latest news