Jurgen Klopp’s side secured a commanding lead at Anfield thanks to goals from Daniel Sturridge and Roberto Firmino either side of half-time.
United were unable to beat West Ham United in their FA Cup quarter-final at Old Trafford on Sunday after Anthony Martial’s equaliser rescued a 1-1 draw following Dimitri Payet’s brilliant opener.
Former United midfielder Scholes admitted that he can’t see Louis van Gaal’s players keeping a clean sheet against Liverpool on Thursday night, which means United will need to score at least four times.
“Playing Liverpool here is a total different kettle of fish than it is at Anfield,” Scholes told BT Sport.
“I think you’ll get a bit of time on the ball.
“I am just worried that United won’t be able to stop Liverpool scoring. It may be a problem. United might have to score four.
“But at 2-0, I still think they’re in the game.”
The Red Devils had won their last four games against Liverpool before Thursday night’s 2-0 loss at Anfield.
The 20-time English champions are winless in their last three games in all competitions following defeats by West Brom and Liverpool.
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