The Reds head to Old Trafford with a 2-0 lead in the last 16 tie thanks to their impressive victory at Anfield last week.
United have come in for plenty of criticism for their below-par performance against Jurgen Klopp’s men at Anfield in the first leg of the clash.
The Red Devils had to come from a goal down to earn a 1-1 draw and force a replay against West Ham United in their FA Cup quarter-final on Sunday.
And former United striker Owen is expecting to see Liverpool reach the last eight of Europe’s second tier club competition on Thursday.
Writing in his column for Bet Victor, Owen said: “Liverpool arrive at Old Trafford with a two-goal lead after a comfortable defeat of United in the first leg at Anfield and should qualify with the minimum of fuss in midweek.
“I was commentating on United’s FA Cup quarter-final against West Ham at the weekend and was left far from impressed by Louis van Gaal’s side, who needed a late goal from striker Anthony Martial to earn a replay at Upton Park.
“With their two-goal cushion the Reds should advance to the next round at the expense of their most fierce rivals.”
Liverpool had a free weekend to prepare for the game as they look to take a step closer to winning their first trophy under new manager Klopp.
MORE: The latest football news