The Red Devils make the short trip to the Etihad Stadium as Louis van Gaal’s side look to return to winning ways after their Europa League disappointment on Thursday night.
United drew 1-1 with Liverpool after Philippe Coutinho cancelled out Anthony Martial’s opener to secure a 3-1 aggregate win for the visitors at Old Trafford.
City, on the other hand, set up a quarter-final meeting with Paris Saint-Germain in the Champions League after a goalless draw at The Etihad sealed a 3-1 aggregate victory over Dynamo Kyiv.
Schweinsteiger, who has recently returned from a knee injury, posted a message for his United team-mates ahead of Sunday’s game.
Schweinsteiger wrote: “It’s derby time! #mufc”
Enhanced odds: Get 5/1 on Man City to beat Man Utd
United are in sixth place and four points behind City, who occupy the final Champions League qualifying spot.
The two Manchester clubs played out a goalless draw at Old Trafford in the Premier League earlier this season.
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