The Red Devils head into the game looking to return to winning ways after the disappointment of their 1-1 draw with Stoke City before the international break.
United are aiming to claim the three points against their bitter local rivals as they look to put together a strong run of form.
The Red Devils have made a stuttering start to life under new manager Jose Mourinho and will be looking to gain some consistency in the run-up to Christmas.
Liverpool, meanwhile, have been in good form this season and have already secured victories over the likes of Chelsea, Arsenal and Leicester City so far this term.
Depay has struggled for a regular spot in the United first team this season but will be hoping to be involved on Monday night.
He shared the photo above on his personal Instagram account and wrote: “That weekend feeling!
“No weekend for us though as we have to prepare for the big match on Monday! #GGMU #EnjoyTheWeekend 😀🎉⚽️💪🏾‼️”
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