Herrera will serve a one-game domestic ban after being sent off during Manchester United’s 1-0 loss to Chelsea in the FA Cup quarter-finals on Monday night.
Ibrahimovic is still suspended, while Wayne Rooney, Anthony Martial and Bastian Schweinsteiger are all doubtful for the trip to the Riverside Stadium.
Manchester United will also be without Paul Pogba for the Premier League clash after the midfielder suffered a hamstring injury during the 1-0 win over Rostov in the Europa League last week.
Speaking at his pre-match news conference, Mourinho said: “My teams’ injury records are very, very good.
“It’s very difficult for my players to get injuries and obviously Pogba’s injury was due to an accumulation of fatigue.
“He felt something in the first half and, in the second half, he immediately felt like he couldn’t carry on. Even a physical monster like him couldn’t carry on. But, of course, he was one of the players who never had a rest.
“He played every game. Even at Blackburn [in the Emirates FA Cup], he was on the bench and he played half-an-hour. I think the Monday night game with 10 men also paid a price. So Paul is paying the price.”
Manchester United head into the game looking to claim victory to keep alive their hopes of finishing in the top four this season.
The Red Devils are currently sixth in the table as they bid to break back into the Champions League spots this term.
MORE: Man United latest news
MORE: Arsenal latest news
MORE: Chelsea latest news
MORE: Liverpool latest news