The Manchester United manager rested Ibrahimovic for the visit of Premier League leaders Chelsea at Old Trafford on Sunday afternoon.
The Red Devils eased to a 2-0 win against Antonio Conte’s side thanks to goals from Marcus Rashford and Ander Herrera.
Mourinho restored Ibrahimovic to his starting line-up for the second leg of their Europa League quarter-final.
However, the former Sweden international struggled to find the back of the net despite Manchester United creating plenty of opportunities for their top goal-scorer.
And the 35-year-old appeared to suffer a serious injury following an awkward fall at the end of the 90 minutes in Manchester United’s 2-1 extra-time win against Anderlecht.
“It looks like a nasty one. It looked pretty bad. It’s a worry for Jose Mourinho,” Owen said.
Ibrahimovic moved to Manchester United in a free transfer from Ligue 1 side Paris Saint-Germain in last summer’s transfer window.
The Swedish forward has scored 17 goals in 29 games in the Premier League this season.
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