Bresnan, who picked up four wickets as England saw off the Tigers by eight wickets at Lord’s yesterday, has a stress fracture in his foot.
It comes as a blow to the Yorkshire all-rounder who was looking for another opportunity to stake a claim for an Ashes birth later in the year.
Sidebottom is included ahead of Nottinghamshire teammate Stuart Broad who is once again rested.
BresnanÃ¢â‚¬â„¢s absence weakens EnglandÃ¢â‚¬â„¢s batting options with the selectors now set to make a straight choice between Sidebottom and LordÃ¢â‚¬â„¢s 12th man Ajmal Shahzad.
Uncapped Shahzad, 24, toured Bangladesh earlier in the year but was passed in the pecking order by LordÃ¢â‚¬â„¢s man of the match Steve Finn.
32-year-old Sidebottom has played 22 Tests and was ever present during EnglandÃ¢â‚¬â„¢s World T20 win in the Caribbean last month.
Injuries have damaged his Test prospects but many observers questioned his selection for the final Test in South Africa last winter.
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