Vaughan’s comments come after yesterday’s news that Flintoff will play no part in the rest of the 2010 cricket season as he continues his rehabilitation from a knee operation.
“I donÃ¢â‚¬â„¢t see him playing for England again Ã¢â‚¬â€œ they have moved on without him and are having a lot of success,” Vaughan told BBC Radio 5 Live.
But Vaughan added that he hoped this would not mark the end of the road for the 32-year-old.
“I hope itÃ¢â‚¬â„¢s not the last we see of him, as I know how much hard work heÃ¢â‚¬â„¢s put in over the last six months to get to this stage.
“Maybe Twenty20 cricket is his best option as heÃ¢â‚¬â„¢ll only have to bowl four overs,” he added.
This latest setback casts major doubts over FlintoffÃ¢â‚¬â„¢s aspirations to appear for England in the 2011 World Cup.
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BIOGRAPHY: Anthony Martial