Eoin Morgan and Man of the Match Michael Yardy guided England through a difficult run chase despite the low target of just 127.
Earlier, the spin pairing of Graeme Swann (2-14) and Yardy (1-21) had restricted Pakistan to just 126-4 from their 20 overs as the middle order toiled on a slow turning wicket.
Kamran Akmal was removed early on before Shahzaid Hasan and Mohammad Yousuf took the score on with some lusty blows. But the introduction of EnglandÃ¢â‚¬â„¢s spinners immediately had the desired impact as Yousuf hauled out to Morgan in SwannÃ¢â‚¬â„¢s first over.
From here on the Pakistan innings limped by with only Umar Akmal scoring better than a run a ball, ending on 35 not out.
Shoaib AkhtarÃ¢â‚¬â„¢s pace was a constant threat as he removed Craig Kieswetter for six, yet Steve Davies occupied the crease before being caught for 33.
Two wickets for Shahid Afridi had England reeling on 62-5 as Morgan and Yardy came together.
Akhtar soon went from hero to villain as he dropped a simple chance from Morgan shortly after a miss fielding on the boundary.
And with seventeen deliveries left, Morgan struck the winning runs to underline EnglandÃ¢â‚¬â„¢s supremacy as World Twenty20 champions and give them a 1-0 lead ahead of the second clash on Tuesday.
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BIOGRAPHY: Mohamed Salah