The London Irish back three player, who has scored two tries in his last four England games, replaces Sale Sharks wing Mark Cueto.
“We’ve said all the way through if Delon’s playing well and with form he’s a Test player,” said England manager Martin Johnson.
“Mark [Cueto’s] injury was a factor [he had a back problem earlier in the tournament]. He’s probably a game short of being back to where he should be.”
Johnsonâ€™s other two changes see Northampton Saints lock Courtney Lawes restored to the second row after a two-game ban and Saracens prop Matt Stevens return at loosehead.
They replace Stade Francais lock Tom Palmer and London Irish prop Alex Corbisiero.
Chris Ashton, who tops the Rugby World Cup 2011 try-scoring charts with five, is one of five players starting their fourth game of the tournament, alongside Northampton Saints team mate Ben Foden, Leicester Tigers pair Manu Tuilagi and Dan Cole and Ricoh Black Rams No8 James Haskell.
Bath Rugby flanker Lewis Moody again captains the side on the occasion of his 70th cap and fly half Jonny Wilkinson will make his 90th Test appearance for England.
England: B Foden; C Ashton, M Tuilagi, M Tindall, D Armitage; J Wilkinson, B Youngs; M Stevens, S Thompson, D Cole, L Deacon, C Lawes, T Croft, L Moody (captain), J Haskell. Replacements: D Hartley, A Corbisiero, T Palmer, N Easter, R Wigglesworth, T Flood, M Banahan.
Scotland team: C Paterson; M Evans, J Ansbro, S Lamont, S Danielli; R Jackson, M Blair; A Jacobsen, R Ford, E Murray, R Gray, A Kellock (captain), A Strokosch , J Barclay, R Vernon. Replacements: S Lawson, A Dickinson, N Hines, R Rennie, C Cusiter, D Parks, N De Luca.
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