The Red Devils are five points clear of second-placed City and Sir Alex Ferguson’s side can extend that lead further with victory over the Toffees in the early kick-off.
Later on Sunday afternoon, Roberto Mancini’s men travel to Wolverhampton Wanderers but Ferdinand wants his team-mates to concentrate on what will be a difficult test against David Moyes’ men.
“The key thing is that we have to win against Everton in order to even give ourselves that chance,” Ferdinand told United Review.
“All we’re thinking about at the moment is that game, not what we can or can’t do next weekend or the weekend after that. And Everton always give us a tough game so we need to make sure we do the job properly.”
Liverpool dashed Everton’s hopes of claiming their first silverware since 1995 with a 2-1 victory over the Toffees in the FA Cup semi-final at Wembley.
But Moyes’ side still have the chance to finish ahead of the Reds, and Ferdinand believes Everton will be gunning for three points at Old Trafford.
“They’ve looked really good recently,” Ferdinand said. “Nikica Jelavic has come in and grabbed a few goals – he looks handy – and they’re the sort of side who give their all for the manager.
“They’re desperate to finish above Liverpool in the league this season, especially after losing to them last weekend. They’re coming here with plenty to play for.”
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