The Argentina international missed the 4-0 midweek victory over Aston Villa with the groin injury he picked up at Everton last weekend.
It is one game more that we must play here and we must prepare in the same way
But manager Manuel Pellegrini has confirmed that his “whole squad” is fit for the visit of the Hammers.
“The whole squad is fit,” said Pellegrini.
“It is very important. If you have your whole squad you can choose between all your players – that is the most important thing for a manager.”
City head into the game needing a point to win their second Premier League crown in three years.
And Pellegrini continued: “It is a very important weekend because it is the last game – it is the work from the whole year – but also it is a normal game because I think the best way to do it is to repeat what we did the whole season so far here.
“I think it is very important for the manager to be calm, to try to repeat what we did the whole year preparing for the games here at home.
“It is one game more that we must play here and we must prepare in the same way.”
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