The Uruguay striker sealed a big-money move to Barcelona in July after scoring 31 Premier League goals for the Reds last season.
Liverpool suffered their third league defeat of the season last weekend as they were beaten 3-1 by West Ham at Upton Park.
And Martinez, whose side travel to Anfield on Saturday, feels that Brendan Rodgers’ side are still adapting to life without the prolific forward.
“Every team changes when you change personnel,” said Martinez.
“You need to find different ways of playing and there is a little bit of adaptation with European football because we’re both going through the same period.
“It’s early in the season and it’s about adapting to those demands and having different players and new ways of playing because obviously Luis Suarez was very significant.”
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