Mikel Arteta was forced off in the first half of the north London derby with a suspected calf problem, while Aaron Ramsey picked up what appeared to be a hamstring strain and had to be substituted after half-time.
Jack Wilshere also suffered an ankle injury during the Gunners’ draw with their local rivals at Emirates Stadium.
And Wenger confirmed that both Ramsey and Arteta are set to miss the forthcoming games against Galatasaray and Chelsea.
Wenger said: “I don’t know how long they’ll be out. I think Ramsey is a hamstring and Arteta is a calf. Wilshere [has] an ankle [problem].
“Wilshere, I don’t know. The two others are out for Chelsea for sure.”
The Frenchman admitted that his squad is now looking “short” following the latest injury blows.
“Wilshere, if you look at the incident again, has been tackled and turned his ankle over,” he said.
“Ramsey is a concern that he did his hamstring. I don’t understand because he had a good rest this week, I didn’t play him against Southampton [in the 2-1 League Cup defeat] on Tuesday night. It’s a surprise because he’s usually a resistant boy.
“Suddenly we are short because if we lost three players today, and let’s not forgot that we already have two out long-term plus Walcott, that’s six. [Abou] Diaby is not ready so it starts to become a worry.”
MORE: Man United latest news
MORE: Arsenal latest news
MORE: Chelsea latest news
MORE: Liverpool latest news