The Leinster back-row forward replaces injured club team-mate Jamie Heaslip at number eight in the only change to the side that defeated France 18-11 in round two on 14 February.
Ireland captain Paul O’Connell, who wins his 99th cap for Ireland, again leads the side from the second row in the potential championship showdown in Dublin.
The backline is unchanged with as Munster’s Conor Murray and Racing Metro’s Johnny Sexton continue at half-back while Connacht’s Robbie Henshaw and Ulster’s Jared Payne continue in midfield.
Head coach Joe Schmidt has made two changes to the bench as Leinster scrum-half Eoin Reddan replaces Isaac Boss – who captained Leinster in the Guinness PRO12 draw with the Ospreys in Swansea tonight.
The other change sees Munster’s versatile back-row forward Tommy O’Donnell take Murphy’s place.
Ireland: Rob Kearney (Leinster); Tommy Bowe (Ulster), Jared Payne (Ulster), Robbie Henshaw (Connacht), Simon Zebo (Munster); Johnny Sexton (Racing Metro), Conor Murray (Munster); Jack McGrath (Leinster), Rory Best (Ulster), Mike Ross (Leinster), Devin Toner (Leinster), Paul O’Connell (Munster, captain), Peter O’Mahony (Munster), Sean O’Brien (Leinster), Jordi Murphy (Leinster).
Replacements: Sean Cronin (Leinster), Cian Healy (Leinster), Martin Moore (Leinster), Iain Henderson (Ulster), Tommy O’Donnell (Munster); Eoin Reddan (Leinster), Ian Madigan (Leinster), Felix Jones (Munster).
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