The north London side travel to Stade Louis II looking to overturn a 3-1 first-leg deficit of goals from Geoffrey Kondogbia, Dimitar Berbatov and Yannick Ferreira-Carrasco.
Arsenal centre-half Koscielny accepted the Gunners need to produce a near-perfect performance against the Ligue 1 side to have any chance of executing a comeback.
Koscielny told Arsenal’s website: “The most important thing is to be ready, focused and prepare well mentally to have a big fight against a big team.
“When you play against a big team the little details are the most important thing – they can make all the difference.
“It is not me that is important – it is the [whole] team. We need to win, it is not just one player who can score, it is the entire team [if we have] a positive attitude.
“I am a defender and we sometimes have corners and free kicks where we try to help our team to score. These situations are very important now in modern football, it can be a key moment in the game.
“It is very important to be focused and we know that they can change a game.”
This is Arsenal’s 15th consecutive appearance in the last 16. However, Wenger’s men lost at this stage in each of the last four seasons.
The Gunners’ last victory in the round of 16 was against Porto (6-2 aggregate) in 2009/10, since then they have suffered elimination against Barcelona (2010/11), AC Milan (2011/12) and Bayern Munich (2012/13 and 2013/14).
Arsenal have never lost in France, where their record reads seven wins and three draws, whilst Wenger has lost just twice in 16 games against clubs from his home country with the Gunners.
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