Gunners manager Arsene Wenger will be without England international Alex Oxlade-Chamberlain after the Frenchman confirmed the midfielder will be sidelined for three to four weeks due to a hamstring problem.
Uncapped Argentine defender Gabriel Paulista, who was signed in a £16m deal from Villarreal in the January transfer window, is set to return to training on Sunday following his hamstring strain.
Arsenal midfielder Jack Wilshere is still recovering from an ankle problem, however, defensive midfielder Mathieu Flamini is available for the visit of Sam Allardyce’s Hammers side.
The Gunners have won five successive domestic games following a 2-1 reversal at White Hart Lane in February, including a 2-1 victory at Manchester United in the FA Cup quarter-final on Monday night.
Arsenal have won their last nine matches against West Ham in all competitions.
MORE: Man United latest news
MORE: Arsenal latest news
MORE: Chelsea latest news
MORE: Liverpool latest news