Red Rose boss Stuart Lancaster had been tipped to return centre Brad Barritt to his starting XV for the Calcutta Cup clash at Twickenham on Saturday.
But the Saracens star (pictured above) suffered suspected knee ligament damage after contesting a high ball in the second half of their 26-17 win at Wasps on Sunday.
While he waved away stretchers to hobble off the field, Barritt and the England coaches are now awaiting the result of scans amid fears that the 28-year-old could be sidelined for at least two months.
The injury is likely to hand a reprieve to Northampton Saints centre Luther Burrell, who started the first three rounds of the championship, if he recovers from a calf problem.
But waiting in the wings is Gloucester’s Billy Twelvetrees, who came through the Cherry and White’s 33-33 draw with the Saints on Saturday.
Saints flanker Tom Wood’s chances of a recall also received a boost after Leicester’s Tom Croft, who has started all three matches of the championship so far on the bench, looks set to be ruled out of the rest of the season with a dislocated shoulder.
Bath prop Henry Thomas was another injury casualty from round 17 of the Aviva Paremiership, going off with an arm injury in his side’s 12-3 win over Sale Sharks on Friday night.
Lancaster is expected to name his team to take on Vern Cotter’s Scotland on Wednesday.
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