The Blues are currently without Thibaut Courtois, Branislav Ivanovic, Loic Remy and Pedro Rodriguez and the Chelsea manager revealed that neither of the four players would be fit for the trip to Upton Park.
Asked about the injury situation, Mourinho told a news conference on Friday afternoon: “The same, exactly the same.”
Chelsea head into Saturday’s game looking to build on their win over Aston Villa in the Premier League at Stamford Bridge last weekend.
The Blues, who are currently 10 points behind leaders Manchester City, played out a goalless draw with Dynamo Kyiv in the Champions League on Tuesday night.
West Ham have won just one of their last 18 Premier League meetings with Chelsea but the Blues have only won one of their last five away games in the top flight.
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