Both sides head into the game struggling to find consistent form and on the back of thrilling 3-3 draws in midweek.
Liverpool came from behind to secure a point against Arsenal thanks to Joe Allen’s stoppage-time goal at Anfield on Wednesday night.
United, meanwhile, twice squandered the lead as they were forced to settle for a point from their game against Newcastle United at St James’ Park the night before.
Liverpool have only won four of their least 10 Premier League games under newly-appointed manager Klopp.
The Red Devils have also struggled in recent weeks and have recorded just three wins form their last 10 top-flight outings.
However, former England and Liverpool winger Barnes is tipping the Reds to make home advantage count and secure a narrow 1-0 win over United at Anfield.
Barnes wrote on his blog for Titanbet: “This game’s always a tough one to call, but I think that with the Anfield crowd behind them Liverpool will have enough to edge out a Manchester United side that don’t score many goals. Goal-scorer – Christian Benteke.”
MORE: Man United latest news
MORE: Arsenal latest news
MORE: Chelsea latest news
MORE: Liverpool latest news