The Gunners are looking to bounce back from the disappointment of their 1-0 loss to Chelsea last month as they bid to get their top-flight title challenge back on track.
Arsene Wenger watched his side book their place in the fifth round of the FA Cup on Saturday afternoon as they sealed a 2-1 win over Burnley to set up a tie with Hull City later this month.
Arsenal head into Tuesday’s clash with the Saints in third place in the table and three points behind leaders Leicester City.
And former Liverpool man Lawrenson is expecting to see Arsenal gain revenge for their 4-0 loss to the Saints on Boxing Day by winning 2-0 this week.
Lawrenson told BBC Sport: “February is a massive month for Arsenal, because they play in every competition that they are left in – the Premier League, Champions League and FA Cup.
“If they are going to win the Premier League, they have to deal with teams like Southampton and despatch them at home.
“Southampton have been playing three at the back of late, and looking very comfortable, and Ronald Koeman’s new formation has also seen them do well with two up front.
“But if they play with two strikers at the Emirates Stadium, I only see one outcome. Arsenal to win, and make up for their no-show in their 4-0 defeat at St Mary’s on Boxing Day.”
Arsenal have not won the Premier League since the 2003-04 season.
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