The Blues head into the game looking to return to winning ways after they were held to a 1-1 draw by Stoke City in the Premier League on Saturday.
Chelsea currently trail PSG 2-1 after they suffered defeat in the first leg of the European tie in Paris last month.
With the west London club currently languishing in 10th place in the Premier League table, their best chance of qualifying for next season’s Champions League may come through winning the competition this season.
Chelsea have shown signs of improvement since Guus Hiddink’s appointment as interim boss.
However, former Arsenal man Nicholas reckons Chelsea are going to be held to a 1-1 draw at Stamford Bridge on Wednesday, a result which would see them be eliminated from the competition for the second season running.
Nicholas told Sky Sports: “I really do think the absence of John Terry is a massive blow. You need a man with a cool head to lead you in situations like this and the task facing Chelsea could overawe them.
“I can see Diego Costa getting frustrated and involved in too many personal battles with PSG’s Brazilian centre-back duo if things aren’t going his way. You need to keep your discipline on nights like this.
“Chelsea have got it in them to win this and then suddenly they’re believing they can win the competition, but I just sense PSG have a goal in them, which would make things very difficult.
“I wouldn’t be surprised if we have a reverse of the 2-1 scorelines and extra time, but I’m leaning towards PSG turning up, doing a professional job and just having enough to see them through, with Edinson Cavani being the man to do the damage again.”
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