The Reds welcome their bitter Premier League rivals to Anfield fresh from a three-game winning streak in the English top flight.
Liverpool have scored 11 times in victories over basement club Aston Villa, fourth-placed Manchester City and Alan Pardew’s Crystal Palace side.
England midfielder Lallana, who scored in Liverpool’s 3-0 win against City at Anfield last week, was bullish over the Reds’s chances of beating United.
“We’ve played well against so called bigger teams this season. We’re confident we can get through over the two legs,” Lallana told his pre-match media conference.
Liverpool are unbeaten in eight European games this season (W3 D5), and have not lost in six Uefa home matches (W3 D3).
Enhanced odds: Get 7/1 on Liverpool to beat Man Utd
They have not lost in eight UEFA Europa League home fixtures (W5 D3) since a 3-2 defeat by Udinese Calcio in the 2012/13 group stage.
United’s record in six Europa League matches to date is W2 D0 L4 (W1 D0 L2 at home – W1 D0 L2 away).
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