Liverpool head into Thursday’s clash with the Red Devils looking to build on their impressive 2-0 win in the last 16 first leg clash last week at Anfield.
United know that the will need to score at least three goals to progress through to the last eight of Europe’s second tier club competition.
And although former Arsenal defender Keown is expecting to see United put up a fight, he is tipping Liverpool to make it through.
Keown told the Daily Mail: “Old Trafford was once a cauldron and it has to be again tonight. The occasion will force the players to improve but United can’t afford to play it so safe all the time. They have to go for it.
“This could be an opportunity for Louis van Gaal and United to really turn things around again, especially if they pull of a comeback like this.
“It could be a defining match for Van Gaal and I expect an improved performance, but I still think Liverpool will win and go through.”
Liverpool and United have met in 166 domestic league games (United 67-55 ahead in terms of wins) and 18 times in various domestic cup competitions (United 11-7 ahead in victories).
United have won all of their European home games against English sides, while Liverpool have yet to win away against English rivals in a European game.
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