The Gunners lost Per Mertesacker and Gabriel Paulista to injury during Tuesday night’s 4-0 victory over Hull City in the FA Cup fifth-round replay at KC Stadium.
France international Laurent Koscielny is already sidelined with injury and the centre-half hasn’t featured since a 3-2 defeat by Manchester United last month.
Former Chelsea midfielder Nevin believes Arsenal’s chances of winning the Premier League title took a blow on Tuesday night following their more injury problems.
“They’ve got a game against Watford in the FA Cup. What an earth will he do with the defence? He is possibly missing all three centre-halves after the problem at Hull,” Wenger told BBC Radio Five Live.
“It’s a real worry for what is coming up, not just the FA Cup but Barcelona after that and the charge for the league title. It is all becoming less and less likely.
“If he had gone out and he hand’t got any injuries, it may have been the best thing if he wants to win the league. As it is, they’re still in the FA Cup and the Champions League, and they’ve still go on outside chance of the Premier League, but it is fading because of the injuries.”
Wales international Aaron Ramsey was also forced off during the FA Cup replay due to an injury problem.
The Gunners host Watford in the FA Cup quarter-final at the Emirates Stadium on Saturday evening.
Arsenal make the trip to Barcelona next week for the second leg of their Champions League last-16 tie at Camp Nou following a 2-0 defeat last month.
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