The north London club are expected to be one of the busiest sides in the summer transfer window as the Gunners look to bounce back from the disappointment of a trophyless season.
Arsenal are said to be on the lookout for defensive reinforcements as Wenger looks to add some more stability to his back-line.
Now, the Daily Express is reporting that Arsenal have expressed an interest in signing Musacchio this summer.
The same report claims that both Manchester United and Barcelona have also kept tabs on the defender in recent months.
The story goes on to say that Wenger has told Arsenal chiefs that he wants a new defensive partner for Laurent Koscielny at Emirates Stadium.
Arsenal ended up second in the Premier League table last season, 10 points behind champions Leicester City.
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