The Belgium international was substituted in the second half of Tottenham’s 1-1 draw with West Bromwich Albion after Alderweireld collided with his centre-half partner Jan Vertonghen.
The former Atletico Madrid defender has helped Tottenham secure the best defensive record in the Premier League this season after conceding just four times in eight top-flight games.
Former Leicester City midfielder Savage warned Tottenham that Alderweireld’s injury would be a massive blow to their title prospects given his influence on Pochettino’s defence.
“Toby Alderweireld went off – that could be a huge blow,” Savage told BBC Radio Five Live.
“Those two as a centre-half pairing have been absolutely magnificent. You’ve only conceded four goals and you’ve the best defensive record in the Premier League again.”
Tottenham salvaged a point at the Hawthorns Stadium after Dele Alli netted an added-time equaliser to cancel out Nacer Chadli’s opener on Saturday afternoon.
The Lilywhites are in third place in the Premier League table and a point behind leaders Manchester City and bitter north London rivals Arsenal after eight games.
Tottenham will make the trip to Eddie Howe’s Bournemouth side in their next Premier League game at the Vitality Stadium next Saturday.
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