The Red Devils will entertain the Premier League leaders a matter of days after the first leg of their Europa League quarter-final at Anderlecht on Thursday night.
Chelsea have beaten Manchester City and Bournemouth in their last two Premier League games to cement their seven-point lead at the top of the Premier League table.
The Blues were 4-0 winners against their former manager Jose Mourinho and his Manchester United side in the Premier League in west London back in October.
Chelsea edged to a 1-0 victory over the Red Devils in the FA Cup last eight last month following N’Golo Kante’s long-range goal at Stamford Bridge.
Former Blues defender Desailly is backing Chelsea to beat Manchester United for the third time in the 2016-17 campaign on Sunday afternoon.
“I’m not sure you change much,” Desailly said.
“His tactical set-up can face any sort of team. Manchester United like to play with speed and on the counter-attack so I’m sure that it is going to be a very good game to watch.
“I think it will be the first team who makes a mistake who will pay [for it] straight away – and I think that will be Manchester United. The ability and the spirit is more with Chelsea in this type of game.”
Chelsea are sitting at the top of the Premier League table and seven points clear of second-placed Tottenham Hotspur.
Marcel Desailly was speaking at the TAG Heuer Premier League Pressure Test. TAG Heuer is the first ever Official Timekeeper and Official Watch of the Premier League.
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