The English champions won the title with two games to spare last season as Antonio Conte got his hands on the Premier League crown in his first term in charge at Stamford Bridge.
However, the Italian coach has endured a frustrating summer after Chelsea missed out on a number of top transfer targets.
And Chelsea made a worrying start to their Premier League opener when new club captain Gary Cahill was sent off for a reckless challenge.
Burnley scored three times in 25 first-half minutes thanks to Sam Vokes’ double and Stephen Ward’s sensational solo goal to leave Chelsea 3-0 down at half-time.
The Blues brought on summer signing Alvaro Morata in the second half and the Spain international netted in the 69th minute to offer hope of a comeback.
But Cesc Fabregas’ sending off for a second bookable offence condemned Chelsea to an opening day defeat despite David Luiz’s late consolation goal.
Former Tottenham striker Lineker delivered his thoughts on a result that will concern Blues fans.
Lineker wrote on Twitter: “Chelsea down to 9 men. Fabregas departs. Not the greatest of starts for the champions.”
Chelsea famously finished in tenth place in the Premier League in 2015-16 despite winning the Premier League title in the previous season under Jose Mourinho.
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