The Red Devils are preparing to travel to Anfield to take on their bitter local rivals as they look to continue their fine start to the new Premier League season.
Manchester United are currently in second place in the Premier League table and level on points with leaders Manchester City after winning six of their opening seven games in the top flight.
Liverpool, meanwhile, are aiming to improve their form in the Premier League after a stuttering start to the new season.
The Merseyside outfit have only won three of their opening seven Premier League games to leave them in seventh place in the table and seven points off top spot.
However, Liverpool have produced some impressive displays this season, including their brilliant performance in the 4-0 victory over Arsenal back in August.
And speaking to Sky Sports, former Manchester United defender Neville outlined why he thinks the first part of the game will be crucial on Saturday.
“I think Jose Mourinho will know on Saturday, after going there last season when he couldn’t afford to lose and with a team that weren’t in a good place, that he has a plan which can be effective,” Neville said.
“This time it is Liverpool who need to win this fixture and I would expect a lot more from United in terms of being on the front foot.
“Liverpool can only play one way and are always devastating in that first 30 minutes, so United have to survive that. That first half-an-hour is crucial and Mourinho will know that.
“It always felt that way when I played at Anfield that if you can get through that first 30 minutes then it becomes a different game and you can start to play a bit more.
“It suits Mourinho in terms of his mentality. What I would expect is similar tactics from last season but with more ambition on the counter-attack.”
Manchester United are aiming to win the Premier League title this season for the first time since their final triumph under Sir Alex Ferguson in 2013.
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