The Red Devils head into the game looking to continue their recent good form after they won six of their opening seven games.
Jose Mourinho’s men are second in the table and level on points with leaders Manchester City as they bid to try and win the title in the Portuguese coach’s second season at the club.
Pogba is currently sidelined with hamstring injury and it has not yet been confirmed when the French midfielder will be back in action.
Neville feels that the France international will be a big miss for the Red Devils against Liverpool, and reckons that his absence means Manchester United are likely to defend deeply because of him not being available.
Neville told Sky Sports: “Paul Pogba is a big absence with his arrogance on the ball, so they will defend deep and be compact again, but whereas there was a back six at times away at Anfield last season, they can commit more on the break.”
Manchester United were 4-0 winners over Crystal Palace at Old Trafford in their most recent Premier League game before the international break.
The Red Devils, who have not won the title since 2013, finished sixth in the Premier League but won both the Europa League and League Cup in Mourinho’s first campaign in charge last season.
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