The Red Devils will welcome the Premier League leaders to the Theatre of Dreams as the 20-time English champions look to halt Manchester City’s 13-game winning run.
Pep Guardiola’s side have the chance to set a new Premier League record with a 14th successive win this weekend but must do so without their talismanic captain Vincent Kompany.
Manchester United will be missing their club-record signing Paul Pogba after the versatile midfielder received a straight red card in a 3-1 win at title rivals Arsenal last weekend.
The 25-year-old scored a goal and made an assist to help Manchester United secure three points at the FA Cup holders last weekend but his creativity will be absent in Sunday’s derby.
Manchester City have won 14 of their 15 games in the Premier League this season, including victories over Arsenal, Liverpool and title holders Chelsea.
Former Liverpool defender Lawrenson believes Manchester United will still manage to secure three points without Pogba this weekend.
“Paul Pogba is out for Manchester United and, while it looks like David Silva will be fit for City, they have a worry over their captain Vincent Kompany,” Lawrenson told BBC Sport.
“That doubt over Kompany is part of the reason I am predicting City’s first defeat of the season.
“I just think United have hit a run of form, and their win at Arsenal last week was very comfortable and impressive.
“If Kompany is missing, that will give United more opportunities from set-peces and, although City will create plenty of chances themselves, David de Gea is obviously in such fine form in goal for Jose Mourinho’s side.
“The key will be what Mourinho tries tactically. You know he will have a plan, and he will have had a team in mind for the past three or four matches too.
“So Pogba’s suspension is a blow for him as far as that is concerned, but I just have a feeling United will go and beat City, in not a particularly good game.”
Manchester United finished in sixth place in the Premier League last term but won the Europa League and the League Cup.
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