The Germany international pulled out of international duty earlier this week following a troublesome back problem in Liverpool FC’s last Premier League game.
Can was forced off the pitch during the 5-0 win due to the fitness setback to raise questions about his participation at Selhurst Park.
The 23-year-old is facing speculation surrounding his future as the Liverpool FC midfielder continues to run down his contract.
Speaking at his pre-match media conference ahead of Liverpool FC’s trip to Palace this weekend, Klopp confirmed that Can won’t feature in the English capital.
“Emre is out for the weekend,” Klopp said.
“[He is] getting better and better and better, much better. Hopefully he can have a normal session with us on Sunday morning and then should be fine again.”
Liverpool FC were 5-0 winners against Watford at Anfield in the Premier League before the international break thanks in part to Mohamed Salah’s four-goal haul.
The Reds are in third place in the Premier League table and two points adrift of Manchester United in the race to secure a top-four finish.
Liverpool FC will take on Premier League leaders Manchester City in the Champions League quarter-final at Anfield next week.
Can has scored three times and has made four assists in 26 appearances in the Premier League this term.
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