The Reds are preparing to travel to south London as they look try and finish their Premier League campaign on a high and cement a top-four finish for the second season running.
Jurgen Klopp’s men are currently in third place in the Premier League table as they bid to try and secure a spot in the Champions League for next season.
The Reds have been in good form in recent weeks and head into the game on the back of their 5-0 thrashing of Watford at Anfield before the international break.
And Karius, who has been keeping Simon Mignolet out of the team as Liverpool’s top goalkeeper in recent weeks, is expecting a tough test when the Reds come up against Roy Hodgson’s men on Saturday.
Speaking in an interview with Sky Sports, Karius said: “I think in general, there are no games in the Premier League where you think ‘oh that’s an easy one’.
“Sometimes we might have made it look easy with how good we were on that day so we will go into the game 100 per cent focused. We know what Crystal Palace can do and what they are good at.
“I think there was a game there last season with ups and downs but we won it so our main target is to win the game, although it is going to be difficult.
“It’s not an easy place to go to, it is an away game and they are fighting for relegation so they will be at 100 per cent and that’s what we have to do too. I think we can get the three points.”
Liverpool FC will take on Manchester City in the first leg of their Champions League quarter-final showdown at Anfield on Wednesday night.
The Reds are aiming to finish in the top four and go as far as possible in Europe’s elite club competition this season.
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