The Reds will make the short trip to Old Trafford in the English top flight in the Premier League weekend’s early kick-off between the top-four rivals.
Liverpool FC signed Van Dijk in a club record £75m deal from Premier League side Southampton in the January transfer window.
The world’s most-expensive defender was rested for Liverpool FC’s goalless draw with FC Porto in the second leg of their Champions League last-16 clash.
Lukaku helped Manchester United to come from 2-0 down with a goal to help Jose Mourinho’s men secured a 3-2 win over Crystal Palace on Monday night.
The Belgian forward has scored 14 goals in 28 games in the Premier League this season to hit the ground running at Old Trafford.
Former Liverpool FC midfielder Hamann is backing Van Dijk to limit Lukaku’s impact on the Premier League clash on Saturday afternoon.
“Yes, I think he will [keep Lukaku quiet],” Hamann told Tag Heuer.
“He is probably as tall as him, think he’s probably as quick as him, and I don’t think Van Dijk minds a physical challenge. You know you can never keep him out the game for 90 minutes Lukaku, because he is just too powerful and too quick and too strong for that.
“But I think Van Dijk will stand up to that challenge. The less service you give Lukaku, or the less you can stop the people giving service to Lukaku the better.”
Manchester United finished in sixth place in the Premier League table last term but ended up winning the Europa League and the League Cup.
Liverpool FC secured a fourth-placed finish in Jurgen Klopp’s first full season at Anfield.
Dietmar Hamann was speaking on behalf of TAG Heuer to promote the TAG Heuer Premier League Pressure Test. TAG Heuer is the Official Timekeeping Partner of the Premier League.
MORE: Man United latest news
MORE: Arsenal latest news
MORE: Chelsea latest news
MORE: Liverpool latest news